Dr. Anil Shelke

Postdoc training: Prof. Bob Williams (Colorado State University), Cetya Therapeutics, and Prof. Joel Freundlich (Rutgers)

PhD advisor: Prof. Gurunath M. Suryavanshi (CSIR-National Chemical Laboratory, NCL)

PROJECT LEAD / FIRST AUTHOR

“Synthesis and development of second-generation β-Ketoacyl-ACP-synthase (KasA) inhibitors” Shelke, A.M. and Freundlich, J.S. (Manuscript Under Preparation, 2022).

“Improved total synthesis of the peptide isostere of Largazole” Shelke, A.M.; Reddy, K.S.N; Dey, S.; Yasuda, N.; Junker, L.H.; Hendrick, C.L.; Williams, R.M. (Manuscript Under Preparation 2022).

“[4+2] Cycloaddition of in situ generated 1,2-diaza-1,3-dienes with arynes: facile approach to 1,4-dihydrocinnolines” Shelke, A.M. and Suryavanshi, G. (Manuscript under preparation).

“Fluoride-assisted synthesis of 1,4,5,6-tetrahydropyridazines via [4+2] cyclodimerization of in situ generated azoalkenes followed by a C-N bond cleavage” Shelke, A.M. and Suryavanshi, G. Organic Letters, 18, 3968-71 (2016).

“Formal synthesis of pinolide via L-proline-catalyzed sequential α-aminooxylation, Horner-Wadsworth-Emmons olefination and Sharpless asymmetric dihydroxylation” Shelke, A.M. and Suryavanshi, G. Tetrahedron: Asymmetry, 27(2), 142-7 (2016).

"An efficient one pot regioselective synthesis of a 3,3’-spirophosphonylpyrazole- oxindole framework via base mediated [1,3]-dipolar cycloaddition reaction of the Bestmann-Ohira reagent with methyleneindolinones” Shelke, A.M. and Suryavanshi, G. Organic & Biomolecular Chemistry, 13, 8669-75 (2015).

“An efficient organocatalytic route for asymmetric total synthesis of Stagonolide F” Shelke, A.M. and Suryavanshi, G. Tetrahedron Letters, 56(45): 6207-9 (2015).

"A short enantioselective synthesis of 3-epi-jaspine B and (+)-oxybiotin via an intramolecular tandem desilylation oxa-Michael addition strategy” Shelke, A.M.; Rawat, V.; Sudalai, A.; Suryavanshi, G. RSC. Advances, 91(4), 49770-4 (2014).

“Asymmetric synthesis of (+)-Stagonolide C and (-)-Aspinolide A via organocatalysis” Shelke, A.M.; Rawat, V.; Sudalai, A.; Suryavanshi, G. Tetrahedron: Asymmetry, 23(22): 1534-41 (2012).

“Development of amidase-dependent pyrazinoic acid prodrugs with activity against pyrazinamide resistant Mycobacterium tuberculosis” Levine, C.; Jadhav, R.; Pan, Y.; Tsotetsi, K.; Wang, X.; Awasthi, D.; Grady, C.; Shelke, A. M.; Daher, S.S.; Richmann, T.; Shrestha, R.; Sukheja, P.; Barnett, P.R.; Dikdan, R.J.; Kim, T.; Russo, R.; Zimmerman, M.; Dartois, V.; Freundlich, J.S. *; Alland, D.; Kumar, P. (Manuscript Under Revision, PNAS, 2022 – bioRxiv).

“Metal-free annulation of β-acylamino ketones: facile access to spirooxazolines and oxazolines via oxidative C-O bond formation” Chavan S.S., Rupanwar, B.D.; Kamble R. B. Shelke, A.M.; Suryavanshi, G. Organic Chemistry Frontiers, 5, 544-48 (2018).

“Triflic acid-catalyzed metal-free synthesis of (E)-2-cyanoacrylamides and 3-substituted azetidine-2,4-diones” Rupanwar, B.D.; Chavan S.S., Shelke, A.M.; Suryavanshi, G. New Journal of Chemistry, 42, 6433-40 (2018).

“An efficient Sn(II)-catalyzed one-pot synthesis of a 3-substituted azetidine-2,4-dione framework” Chavan S.S., Supekar M.V.; Burhate P.A.; Rupanwar, B.D.; Shelke, A.M.; Suryavanshi, G. Organic & Biomolecular Chemistry, 15, 2385-91 (2017).